This 18th-century mansion with its elegant proportions originally had a total area of 4,800 square metres including the courtyard and garden. Its central building and two wings overlooked the main courtyard to the south, fronting the rue Saint-Dominique, and the interior garden to the north.
It was built in 1708 and lived in by Frédéric-Maurice de la Tour, the Count of Auvergne and Lieutenant General to King Louis XIV, before passing to his son Cardinal Henri de la Tour d’Auvergne.
In 1764 it became the property of the Count of Caraman, a Field Marshal who was promoted in 1780 to Lieutenant General to King Louis XVI. The family emigrated during the French Revolution, returning to Paris in 1801. The mansion remained in the family until 1820, when it was bought by Count de La Rochefoucauld, a French ambassador. His son, the Duke of Estissac, and his descendants kept it until 1929.
The location and the mansion were suitable for the La Maison de la Chimie project. The purchase price was 13 million French francs, including two million for the furniture and works of art.
The French government gave its agreement and submitted a bill to Parliament, which was approved unanimously by both Houses and enacted on 8 August 1929. The Foundation’s ‘public interest’ status was granted by decree on 12 August 1928. An international fund-raising campaign in 1930 amassed 24,895,240 French francs, the equivalent of around €10.5 million today.
The architectural policy was to preserve the building’s overall layout and style, which gave it its charm. The exterior of the central building remained untouched and all interior decorationwoodwork, floors and wall coveringswere restored. This huge building was fitted out with the most up-to-date facilities, harmoniously blending the original features with the 1930s additions.